Prostacyclin (PGI2) effets on anterior pituitary hormones in the rat in vivo |
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| Authors: | F.A. Kimball S.E. Porteus K.T. Kirton R.D. Frielink D.M. Creasy A.D. Dayan |
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| Affiliation: | 1. Fertility Research The Upjohn Company Kalamazoo, Michigan 49001 USA;2. Department of Pathology Wellcome Research Laboratories Beckenham, U.K. |
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| Abstract: | Intravenous injection of 600 μg PGE2 or PGI2 significantly increased serum LH and prolactin levels in estradiol treated ovariectomized rats. There was no effect on serum FSH concentration. PGE2 and PGI2 stimulated LH release in a non-dose dependent manner, while prolactin levels were positively correlated with the dose administered following PGI2 treatment. 6-keto-PGF1α at a comparable dose had no effect on pituitary hormone levels. Subcutaneous administration of 1 mg/kg or 60 mg/kg PGI2 for seven days significantly depressed serum LH level both in male and female rats. These doses had no effect on serum FSH or prolactin levels. |
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