About Mechanisms Responsible for the Depression of Alcohol Motivation Resulting from the Immunization of Albino Rats against Alcohol Dehydrogenase I: The Role of ADH Epitopes and ADH Activity in the Adrenals |
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| Authors: | R. A. Danilova V. N. Prozorovskii T. A. Moskvitina M. F. Obukhova M. L. Lovat' I. M. Fedorova I. P. Ashmarin |
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| Affiliation: | (1) Biology Department, Moscow State University, Vorob'evy gory, Moscow, 119899, Russia;(2) Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832, Russia |
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| Abstract: | Experimental results have demonstrated a significant decrease in the level of alcohol consumption by albino rats immunized with heterologous horse alcohol dehydrogenase. The role of ADH epitopes 9–14, 93–115, and 265–276 in this phenomenon was examined, and it was established that the latter sequence (265–276) plays the biggest role. The inhibition of ADH activity in the adrenals of immunized rats was much higher compared to the liver. We propose a hypothesis that the effect of alcohol dehydrogenase on alcohol consumption is connected with its role in catecholamine metabolism. |
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