Plasma hepcidin in early-stage breast cancer patients: no relationship with interleukin-6, erythropoietin and erythroferrone |
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| Authors: | Chiara Maura Ciniselli Maida De Bortoli Elena Taverna Luca Varinelli Sara Pizzamiglio Silvia Veneroni |
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| Affiliation: | 1. Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;2. Laboratory of Proteomics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;3. Biomarkers Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy |
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| Abstract: | Objective: Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breast disease or cancer. Methods: Plasma samples from a cohort of 131 patients (47 with benign breast disease and 84 with breast cancer) were subjected to the evaluation of hepcidin, IL-6, EPO and ERFE using SELDI-TOF-MS or immunoassays. Results: An elevated hepcidin was observed in malignant breast tumors compared to benign ones. No correlation was observed between hepcidin and IL-6, EPO or ERFE. Conclusion: Since the study included a cohort of patients (87%) with breast cancers smaller than 2 cm, these results may support our previous evidence about the potential role of hepcidin in breast cancer disease. |
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| Keywords: | benign breast disease BMP6 breast cancer early diagnosis erytroferrone erytropoiesis erytropoietin hepcidin IL-6 inflammation iron metabolism |
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