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Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions
Institution:1. School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK;2. Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK;3. Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA;4. Department of Medical Microbiology, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands;5. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7FZ, UK;6. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA;7. Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;8. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
Abstract:
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  • Keywords:glycans  human immunodeficiency virus  vaccines  broadly neutralizing antibodies  mass spectrometry  cryo-electron microscopy  glycosylation  structure
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