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Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation
Institution:1. Department of Biomedical Sciences for Health, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy;2. Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20133 Milan, Italy;3. Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, Piazza Malan 2, San Donato Milanese, 20097 Milan, Italy;4. Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy;5. IRCCS Mondino Foundation, Pavia, Italy;6. University of Vita-Salute San Raffaele, Milan, Italy;1. Supramolecular and Catalysis Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India;2. Medicinal Chemistry Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India;3. Oncology Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India;4. Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India;5. Computational Chemistry Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India;1. Department of Chemistry and Biochemistry, University of Montana, 32 Campus Drive, Missoula, MT 59812, United States;2. Center for Translational Medicine, University of Montana, 32 Campus Drive, Missoula, MT 59812, United States;3. Division of Biological Sciences, University of Montana, 32 Campus Drive, Missoula, MT 59812, United States;1. Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University; Institute of Hematology, Sun Yat-sen University, Guangzhou 510630, China;2. Department of Clinical Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China;3. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China;4. Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;5. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510510, China;6. Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences; School of Medicine, South China University of Technology, Guangzhou 510080, China
Abstract:
Keywords:HMG-CoA reductase  Degradation  SR12813  SR45023A (apomine)  Bisphosphonate esters  Photoaffinity labeling
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