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DNA sequence-specific ligands. XVIII. Synthesis,physico-chemical properties; genetic,virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n)
Affiliation:1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia;2. Emanuel Institute of Biochemical Physics, RAS, Moscow 119334, Russia;3. Scientific Center “Kurchatov Institute”, Research Institute of Genetics & Selection of Industrial Microorganisms, Moscow 117545, Russia;4. Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow 123098, Russia;5. Department of Chemistry and Belozersky Institute of Physicochemical Biology, Moscow State University, Moscow 119991, Russia;6. Institute of Carcinogenesis, FSBI “N.N. Blokhin National Medical Research Center of Oncology”, The Ministry of Health of the Russian Federation, 115478 Moscow, Russia;1. Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India;2. P.G. Department of Chemistry, Khalsa College, Amritsar 143001, India;1. Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, 3 I.Chavchavadze Ave., Tbilisi 0128, Georgia;2. Department of Physics, New York City College of Technology, 300 Jay Street, Brooklyn, New York, NY 11201, USA;3. Andronikashvili Institute of Physics, I. Javakhishvili Tbilisi State University, 6 Tamarashvili Str., Tbilisi 0177, Georgia;4. Department of Chemistry, The City College and The City University of New York, 160 Convent Avenue, New York, NY 10031-9198, USA;1. Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, 4-23-15, Koto-bashi, Sumida-ku, Tokyo 130-8575, Japan;2. Department of Emergency Medicine, Tokyo Metropolitan Bokutoh General Hospital, 4-23-15, Koto-bashi, Sumida-ku, Tokyo 130-8575, Japan;3. Department of Infectious Diseases, Tokyo Women''s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan;4. Department of Bacteriology 1, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
Abstract:
Keywords:DNA  Sequence-specific ligands  Fluorescent dimeric bisbenzimidazoles  Protein H-NS  HSV-1  HIV-1 integrase  HSV-1"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  herpes simplex virus type 1  HIV-1"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  human immunodeficiency virus  scDNA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  supercoiled DNA  b.p."  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  base pairs  MABs"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0080"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  monoclonal antibodies  ACV"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0090"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  acyclovir  AHL"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0100"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  acylhomoserine lactones  PBS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0110"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  phosphate buffered saline  PFU/cells"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0120"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  plaque formation units per cells  50% maximal inhibitory concentration  50% maximal cytotoxic concentration  SI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0160"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  selectivity index  QS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0170"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Quorum Sensing  TBTU"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0180"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate  DIPEA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0190"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  N,N-diisopropylethylamine
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