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RNA drug discovery: Conformational restriction enhances specific modulation of the T-box riboswitch function
Institution:1. Department of Chemistry & Biochemistry, Clippinger Laboratory, Ohio University, Athens, OH 45701, USA;2. Molecular & Cellular Biology Program, Ohio University, Athens, OH 45701, USA;3. Edison Biotechnology Institute, Konneker Laboratories, Ohio University, Athens, OH 45701, USA;1. Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA;2. Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA;3. Department of Biomedical Science, Ohio University, Athens, OH 45701, USA;4. Program of Molecular and Cellular Biology, Ohio University, Athens, OH 45701, USA;1. Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, United States;2. Biomedical Engineering Program, Ohio University, Athens, OH 45701, United States;3. Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, United States;4. Department of Specialty Medicine, Ohio University, Athens, OH 45701, United States;5. The Diabetes Institute, Ohio University, Athens, OH 45701, United States;6. Molecular and Cellular Biology Program, Ohio University, Athens, OH 45701, United States;7. Translational Biomedical Sciences Program, Ohio University, Athens, OH 45701, United States
Abstract:
Keywords:RNA  Drug discovery  T-box riboswitch  Allosteric inhibition  Conformational restriction
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