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Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations |
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| Affiliation: | 1. Section of Structural and Synthetic Biology, Faculty of Infectious Diseases, Imperial College London, London SW7 2AZ, UK;2. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA |
| Abstract: |  |
| Keywords: | Serine/Threonine kinase DNA damage response cryo-EM phosphatidylinositol-3-kinase-like kinase genome integrity Ataxia Telangiectasia DNA double-strand break repair phosphorylation telomere maintenance |
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