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Tightening the Crosslinking Distance Restraints for Better Resolution of Protein Structure and Dynamics
Affiliation:1. CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance at Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, Hubei Province 430071, China;2. Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei Province 430074, China;3. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Abstract:
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  • Keywords:chemical crosslinking coupled with mass spectrometry  solvent-accessible surface distance  straight-line distance  chemical modification  distance restraint  structure refinement  protein dynamics  protein-protein interaction  integrative structural biology  26S proteasome
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