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Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases
Affiliation:1. State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China;4. School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China
Abstract:
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  • Keywords:MLL2  KMT2B  P53  histone methylation  epigenetics  RBBP5  ASH2L  protein complex  structural biology  X-ray crystallography
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