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Renaissance of Allostery to Disrupt Protein Kinase Interactions
Affiliation:1. Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET, Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina;2. Department of Internal Medicine I, University Hospital, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany;3. DKTK German Cancer Consortium (DKTK), Frankfurt, Germany;4. German Cancer Research Center (DKFZ), Heidelberg, Germany;1. BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;2. School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China;3. Institute of Systems Biology, Shenzhen Bay Laboratory, Shenzhen 518055, China;4. Center for Quantitative Biology, Peking University, Beijing 100871, China;5. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;1. Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, 3501 Fifth Ave, Suite 3064 BST3, Pittsburgh, PA 15260, USA;2. Research Center for Computer-Aided Drug Discovery, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;1. The Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;2. Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;3. Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA;4. Center for Physics of Evolving Systems, University of Chicago, Chicago, IL 60637, USA;5. Currently unaffiliated independent scientist;1. Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), 30 Biopolis Street, #07-01, Matrix, 138671, Singapore;2. Department of Biological Sciences (DBS), National University of Singapore (NUS), 8 Medical Drive, 117579, Singapore;1. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada;2. Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada;1. Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary;2. Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0654, USA;3. Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0654, USA
Abstract:
Keywords:protein kinase  bidirectional allostery  allostery  protein–protein interaction  protein kinase regulation
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