Promising antifungal agents: A minireview |
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| Institution: | 1. Universidade Estadual de Maringá, Av. Colombo, 5.790 – Jd. Universitário, CEP 87020-900 Maringá, Paraná, Brazil;2. Centro Universitário Integrado, Rodovia BR 158, Km 207, CEP 87300-970 Campo Mourão, Paraná, Brazil;3. Universidade do Estado de Mato Grosso – Campus de Nova Xavantina, Rua Prof. Dr. Renato Figueiro Varella, Caixa Postal 08, CEP 78690-000 Nova Xavantina, Mato Grosso, Brazil;1. Syngenta Crop Protection AG, Chemical Research, Schaffhauserstr. 101, CH-4332 Stein, Switzerland;2. Syngenta Biosciences Pvt. Ltd, Research & Technology Centre, Santa Monica Works, Corlim, Ilhas, Goa 403 110, India;1. Institute of BioPharmaceutical Research, Liaocheng University, 1 Hunan Road, Liaocheng 252000, PR China;2. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan 250012, PR China;1. Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China;2. Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, United States |
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| Abstract: | In the recent past, prevalence of life threatening fungal diseases have increased rapidly in immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer, organ transplant etc. Side by side, the appearance of drug resistance to the presently available antifungal therapeutics is on a rapid rise. It has become a top priority for the academia and pharmaceutical industries to develop new antifungal agents able to combat this resistance, and at the same time, possess potential broad spectrum of activity and minimum toxicity. An understanding of the pharmacological interactions between antifungal agents and their targets offers opportunities for design of new therapeutics. This review discusses the various methodology of drug design, structure activity relationships (SARs), and mode of action of variety of new antifungal agents. |
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| Keywords: | Antifungal agents Antifungal targets Minimum Inhibitory Concentration (MIC) Structure activity relationships (SARs) Zone of inhibition (Z I) |
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