Mechanism of protonophores-mediated induction of heat-shock response in Escherichia coli |
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Authors: | Bimal Jana Subrata Panja Swati Saha and Tarakdas Basu |
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Institution: | (1) Department of Biochemistry and Biophysics, University of Kalyani, Kalyani- 741 235, West Bengal, India |
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Abstract: | Background Protonophores are the agents that dissipate the proton-motive-force (PMF) across E. coli plasma membrane. As the PMF is known to be an energy source for the translocation of membrane and periplasmic proteins after
their initial syntheses in cell cytoplasm, protonophores therefore inhibit the translocation phenomenon. In addition, protonophores
also induce heat-shock-like stress response in E. coli cell. In this study, our motivation was to investigate that how the protonophores-mediated phenomena like inhibition of protein
translocation and induction of heat-shock proteins in E. coli were correlated. |
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Keywords: | |
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