The remote effects of radiation after hypofractionated irradiation with protons of Ehrlich ascites carcinoma in mice |
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| Authors: | V. E. Balakin A. E. Shemyakov S. I. Zaichkina O. M. Rozanova E. N. Smirnova S. P. Romanchenko S. S. Sorokina N. S. Strelnikova |
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| Affiliation: | 1.Physical Technical Center, Lebedev Physical Institute,Russian Academy of Sciences,Protvino, Moscow Region,Russia;2.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow Region,Russia |
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| Abstract: | This work focuses on the study of remote effects (duration of remission, recurrence rate, and average lifespan) in mice with Ehrlich ascites carcinoma exposed to oligofractionated irradiation with a pencil scanning beam of protons depending on the volume of the tissue being irradiated and the interval between dose fractions. The results show higher antitumor efficacy and a considerable increase in the average life span of mice after hypofractionated irradiation with a pencil scanning beam of protons at a total dose of 60 Gy of the gross tumor volume compared with the planning target volume. |
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