|
|||||
|
|
Transgenic assays for mutations and cancer: current status and future perspectives |
|
| Authors: | Jan Vijg Harry van Steeg |
| Affiliation: | a Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA b Laboratory of Health Effects Research, National Institutes of Public Health and the Environment, P.O. Box 1, 3720 BA, Bilthoven, Netherlands |
| Abstract: | Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing. |
| Keywords: | Transgenic mouse model Carcinogenicity Mutagenicity Risk estimation DNA repair gene Tumor suppressor gene lacZ reporter gene |
| 本文献已被 ScienceDirect 等数据库收录！ | |