| 视前区儿茶酚胺神经末梢损毁对针刺镇痛的影响 |
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| 引用本文： | 朱津民,李宽孍,曹小定.视前区儿茶酚胺神经末梢损毁对针刺镇痛的影响[J].生理学报,1990(2). |
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| 作者姓名： | 朱津民 李宽孍 曹小定 |
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| 作者单位： | 上海医科大学神经生物学教研室
(朱津民，李宽孍)，上海医科大学神经生物学教研室(曹小定) |
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| 摘 要： | 本实验在家兔双侧视前区内注入6-羟基多巴胺(6-OH-DA,4μg/每侧),选择性损毁该区儿茶酚胺(CA)神经末梢后,观察对针刺镇痛的影响。实验结果表明,注药后第二、四天,针刺镇痛效应较针前或对照组均有明显提高。注药后第十天,针刺镇痛效应基本恢复到对照组水平。用甲醛诱发荧光组织化学法显示视前区 CA 末梢,可见6-羟基多巴胺组的 CA 末梢明显减少。结果提示,视前区 CA 含量减少有利于针刺镇痛作用。
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| 关 键 词： | 儿茶酚胺神经末梢 视前区 6-羟基多巴胺 针刺镇痛 |
EFFECTS OF DESTRUCTION OF PREOPTIC CATECHOL-AMINERGIC NERVE TERMINALS ON ACUPUNCTURE ANALGESIA |
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| ZHU JIN-MIN,LI KUAN-YAN,CAO XIAO-DING.EFFECTS OF DESTRUCTION OF PREOPTIC CATECHOL-AMINERGIC NERVE TERMINALS ON ACUPUNCTURE ANALGESIA[J].Acta Physiologica Sinica,1990(2). |
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| Authors: | ZHU JIN-MIN LI KUAN-YAN CAO XIAO-DING |
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| Abstract: | The effect of microinjection of 6-hydroxydopamine into the preoptic area wasstudied to observe the effect of destruction of catecholaminergic terminals in thepreoptic area on acupuncture analgesia.It was shown that the analgesic effectof acupuncture was significantly enhanced in 6-hydroxydopamine treated groupon the second and fourth day after injection as compared with those before injectionor those in control group.The fluorecence of catecholamine terminals in thepreoptic area disappeared almost completely on the fourth day after injection,anddid not restore on the tenth day.The data indicate that the reduction of catechol-amine content in the preoptic area may enhance acupuncture analgesia. |
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| Keywords: | catecholaminergic terminal preoptic area 6-hydroxydopamine acupuncture analgesia |
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