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Zinc supplementation aggravates body fat accumulation in genetically obese mice and dietary-obese mice
Authors:Ming-Der Chen  Pi-Yao Lin  Vie Cheng  Wen-Han Lin
Institution:(1) Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, No. 160 Section 3, Taichung-Kang Road, Taichung, Taiwan;(2) Department of Chemistry, Tunghai University, Taichung, Taiwan, No. 181 Section 3, Taichung-Kang Road, 40075 Taichung, Taiwan;(3) Department of Biology, Tunghai University, Taichung, Taiwan, No. 181 Section 3, Taichung-Kang Road, 40075 Taichung, Taiwan
Abstract:A perturbation of zinc metabolism has been noted in numerous laboratory animals with diabetes and obesity. The effects of zinc supplementation on body fat deposition in two types of experimental obese mice: genetically obese (ob/ob) mice and high-fat diet-induced ICR obese (HF) mice were investigated in this study. Their lean controls were +/? mice, and ICR on basal diet, respectively. The mice in the zinc-supplemented groups were administered 200 mg/kg zinc in their diets for 6 wk. Both the ob/ob mice and the HF mice, that were fed a diet containing a marginal zinc dosage (4–6 mg/kg), had lower zinc levels in their serum and carcass, and higher body fat content than their respective lean controls (p<0.01). After zinc supplementation, ob/ob mice and the HF mice significnatly (p<0.05) increased their body fat by 49.4% and 18.9%, respectively. This study revealed that body fat deposition can be aggravated by zinc supplementation in both types of obese mice. Zinc may be associated with the energy homeostasis of obesity, via its interaction with dietary fat consumption.
Keywords:Body fat  dietary-obese mice  ob/ob mice  zinc
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