| Ion channels: does each subunit do something on its own? |
| |
| 引用本文： | Karpen JW,Ruiz M. Ion channels: does each subunit do something on its own?[J]. Trends in biochemical sciences, 2002, 27(8): 402-409. DOI: 10.1016/S0968-0004(02)02124-2 |
| |
| 作者姓名： | Karpen JW Ruiz M |
| |
| 摘 要： |
|
Ion channels: does each subunit do something on its own? |
| |
| Karpen Jeffrey W,Ruiz MariaLuisa. Ion channels: does each subunit do something on its own?[J]. Trends in biochemical sciences, 2002, 27(8): 402-409. DOI: 10.1016/S0968-0004(02)02124-2 |
| |
| Authors: | Karpen Jeffrey W Ruiz MariaLuisa |
| |
| Affiliation: | Department of Physiology and Biophysics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C240, Denver, CO 80262, USA. jeffrey.karpen@uchsc.edu |
| |
| Abstract: | The advent of the patch-clamp technique 25 years ago revolutionized the study of ion channels. This method also made it possible to measure the kinetic behavior of single protein molecules. The low-noise recordings of ionic currents through single channels, coupled with other cutting-edge technologies, have revealed a rich complexity of functional states that are not readily explained by simple allosteric protein models such as the popular concerted model and the sequential model. Although these models can each account for elements of ion channel function, we propose that variations or extensions of the lesser-known general allosteric model provide a more promising framework for explaining the intricate behaviors of ion channels. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
