| 幽门螺杆菌动物模型研究进展 |
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| 引用本文： | 王晓伟,端青,张宝元. 幽门螺杆菌动物模型研究进展[J]. 生物技术通讯, 2002, 13(3): 218-221 |
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| 作者姓名： | 王晓伟 端青 张宝元 |
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| 作者单位： | 1. 首都儿科研究所,北京,100021
2. 军事医学科学院微生物流行病研究所,北京,100071 |
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| 摘 要： | 幽门螺杆菌动物模型用于HP相关疾病和HP疫苗作用的研究。常规实验动物包括悉生猪、悉生狗、非人类灵长动物、猫、雪貂、小鼠、大鼠、沙鼠等。猫螺杆菌和雪貂螺杆菌感染也被用于模型研究。最近，转基因小鼠和基因敲除小鼠也被用作幽门螺杆菌动物模型研究。
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| 关 键 词： | 幽门螺杆菌 动物模型 研究进展 HP |
| 文章编号： | 1009-0002(2002)03-0218-04 |
| 修稿时间： | 2002-01-10 |
Animal models for Helicobacter pylori infections |
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| WANG Xiao-wei ,ZHANG Bao-yuan ,DUAN Qing. Animal models for Helicobacter pylori infections[J]. Letters in Biotechnology, 2002, 13(3): 218-221 |
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| Authors: | WANG Xiao-wei ZHANG Bao-yuan DUAN Qing |
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| Affiliation: | WANG Xiao-wei 1,ZHANG Bao-yuan 1,DUAN Qing 2 |
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| Abstract: | The H.pylori animal models which have been used in pathogenesis and vaccine studies include the gno-tobiotic pig,non-human primates,cats,dogs,and several species of rodents including mice,rats,gerbils and guinea pigs.H.felis infection of mice and H.mustelae infection of ferrets have also been used.Recently,investigators have begun using transgenic mice and gene-targeted'knock-out 'mice to investigate Helicobacter infections. |
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| Keywords: | Helicobacter pylori models animal |
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