Experimental cutaneous primary infection with Cryptococcus neoformans (Sanfelice) Vuillemin

Summary 1. Subcutaneous inoculation into the forelegs of hamsters withC. neoformans following trauma as well as subcutaneous inoculation into the abdominal wall led to infection with dissemination.2. Active skin lesions persisted during the 39 days of the experiment without regression of skin lesions.3. Involvement of lymph nodes was observed in (a few) animals infected with strains 220 and 216 only.4. In addition to the virulence of the strain, the dose of the organisms also affected the degree of infection in the tissues.5 Intratesticular inoculation led to infection with faster and more severe dissemination.6. Schaumann bodies were observed in skin lesions.7. Cortisone accelerated the course of infection.8. Primary skin infection with subsequent I.P. challenge produced a partial protection insofar as the hematogenous spread was concerned.