Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population |
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Authors: | Lance A Bare Edward A Ruiz-Narvaéz Carmen H Tong Andre R Arellano Charles M Rowland Joseph J Catanese Frank M Sacks James J Devlin Hannia Campos |
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Institution: | 1. Celera, Alameda, California, United States of America.; 2. Slone Epidemiology Center, Boston University, Boston, Massachusetts, United States of America.; 3. Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; 4. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.;University of Utah, United States of America |
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Abstract: | Background and MethodologyThe 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations.Principal FindingsCompared with the reference Trp/Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture (OR = 1.12; 95%CI, 0.98–1.28). Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 (95% confidence interval, 1.01–1.34), but this association would not be significant after a multiple testing correction.Conclusions/SignificanceWe found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica. |
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