A comparison of nutritional and genetic blocks in the synthesis of purines by yeasts,molds and bacteria |
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| Authors: | FRIEDMAN H MOAT A G |
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| Affiliation: | 1. School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu Province 73000, China;2. NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Lanzhou, Gansu Province 730000, China;3. Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu Province 73000, China |
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| Abstract: | 5-Aminoimidazole riboside and inosine are accumulated by biotin-deficient yeast. The addition of aspartic acid prevents accumulation of these intermediates in the incubation medium. Purine-requiring yeast, neurospora, and vibrio strains accumulate 5-aminoimidazole riboside but not inosine. Aspartic acid fails to prevent 5-aminoimidazole accumulation, an indication of a genetic block in the ability of these organisms to metabolize this compound further. The relationship of biotin to purine biosynthesis by yeast is discussed in the light of the data presented. |
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