Tracking the physical aging of poly(ethylene oxide): A technical note |
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Authors: | Dorottya Kiss Karoly Süvegh Tamas Marek Laszlo Dévényi Csaba Novák Romána Zelkó |
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Affiliation: | (1) Department of Materials Science and Engineering, McMaster University, Hamilton, Ontario, L8S 4L7, Canada;(2) Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA; |
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Abstract: | Physical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples at 40°C±2°C and 75%±5% RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms. |
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Keywords: | Poly(ethylene oxide) physical aging positron annihilation lifetime spectroscopy differential scanning calorimetry amorphous |
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