Iterleukin 1 alpha is a marker of endothelial cellular senescent |
| |
| Authors: | Massimo Mariotti Sara Castiglioni Daniela Bernardini and Jeanette AM Maier |
| |
| Institution: | (1) Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy |
| |
| Abstract: | Background The functional changes associated with endothelial senescence may be involved in human aging and age-related vascular disorders.
Since the inflammatory cytokine interleukin (IL-)1 inhibits endothelial growth, we evaluated the expression of IL-1α, IL-1β
and their antagonist, the IL-1 receptor antagonist (IL-1ra), in endothelial in vitro senescence and quiescence. We also examined
the expression of IL-1α in human senescent and progeric fibroblasts. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
