Synthesis and potential antimetastatic activity of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosides |
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| Authors: | Li Qing Su Bin Li Hui Meng Xiang-Bao Cai Meng-Shen Li Zhong-Jun Zhou Rou-Li Suo Ta-Lin |
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| Affiliation: | Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China. |
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| Abstract: | Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion. |
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| Keywords: | N-Acetyllactosamine Monovalent Divalent Synthesis Metastasis |
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