Oxidative stress induced by gibberellic acid on kidney tissue of female rats and their progeny: biochemical and histopathological studies |
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| Authors: | Afef Troudi Ibtissem Ben Amara Nejla Soudani Amira Mahjoubi Samet Najiba Zeghal |
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| Institution: | (1) Animal Physiology Laboratory, UR 08-73, Sciences Faculty, University of Sfax, BP 1171, 3000 Sfax, Tunisia;(2) Animal Physiology Laboratory, Department of Life Sciences, Faculty of Sciences, Sfax University, Sfax, Tunisia; |
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| Abstract: | Gibberellic acid (GA3) is an endogenous plant growth regulator used worldwide in agriculture. The objective of this study was to investigate the
effects of GA3 on the kidney function of adult rats and their pups. Female Wistar rats were given daily 200 ppm GA3 in drinking water from the 14th day of pregnancy until day 14 after delivery. GA3 induced nephrotoxicity, as evidenced by a reduction in the 24-h urine volume and an increase in plasma creatinine, urea and
uric acid levels. Nephrotoxicity was objectified by a significant increase of malondialdehyde level and a decrease of antioxidant
enzyme activities like catalase, superoxide dismutase, glutathione peroxidase and glutathione content in kidneys of suckling
pups and their mothers. Kidney histological studies confirmed biochemical parameters. We concluded that the exposure of rats
to GA3 induced oxidative stress and histopathological changes in kidneys of suckling rats and their mothers during late pregnancy
and early postnatal periods. |
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