Chromobodies to Quantify Changes of Endogenous Protein Concentration in Living Cells
Affiliation:
3. Pharmaceutical Biotechnology, Eberhard Karls University Tuebingen, Germany;4. Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
Abstract:
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Highlights
•Chromobodies are stabilized by antigen binding in live cells.
•Monitoring changes of endogenous protein levels in living cells with chromobodies.
•Broadly applicable system to generate turnover-accelerated chromobodies.
•Quantification of time- and dose-dependent compound effects.