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Evaluation of Serum Glycoprotein Biomarker Candidates for Detection of Esophageal Adenocarcinoma and Surveillance of Barrett's Esophagus
Institution:3. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia;4. The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia;5. Envoi Pathology, Brisbane, Queensland, Australia;6. Melbourne Integrative Genomics and School of Mathematics and Statistics, The University of Melbourne, Victoria, Australia;12. Peter MacCallum Cancer Centre, and Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia;8. St Vincent''s Centre for Applied Medical Research and University of Notre Dame School of Medicine, Sydney, Australia;9. Discipline of Surgery, Flinders University, Adelaide, South Australia, Australia;10. Ochsner Health System, Gastroenterology, New Orleans, LA
Abstract:
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  • Highlights
    • •C9, GSN, PON1, and PON3 validated as serum biomarker candidates of EAC.
    • •Multimarker panel with AUROC of 0.93 to aid current endoscopy surveillance of BE.
    • •Induction of tissue C9 in BE, dysplastic BE and EAC.
    • •Alteration of complement pathway glycoproteins during BE-EAC pathogenesis.
    Keywords:Biomarker: Diagnostic  Glycoproteins  Gastrointestinal disease  Cancer biomarker(s)  Targeted mass spectrometry  Multiple reaction monitoring  Serum/Plasma  Barrett's esophagus  Complement pathway  Esophageal adenocarcinoma
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