Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes

Affiliation:	3. KU Leuven, Centre of Microbial and Plant Genetics, Kasteelpark Arenberg 20, Leuven, B-3001, Belgium;4. European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany;5. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Science4Life, Utrecht University, Utrecht, The Netherlands;6. Netherlands Proteomics Centre, Utrecht, The Netherlands;8. Technical University of Berlin, Berlin, Germany;9. Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany

Abstract:	Download : Download high-res image (66KB) Download : Download full-size image Highlights •Novel PTMs detected in native yeast exosome, RNA polymerase II and proteasome. •MD based approach outperforms published tools in predicting PTMs stability effect. •Dynamical approach reveals long range effects of PTMs on subunits binding. •Acetylations may have a role in local stabilization of protein complex formation.

Keywords:	Phosphorylation Acetylation Yeast Structural Biology Computational Biology Binding Affinity Exosome Proteasome Proteomics RNA polymerase II
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