Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits

Institution:	3. Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272;4. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555;5. Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195;6. Department of Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195

Abstract:	Download : Download high-res image (100KB) Download : Download full-size image Highlights •Stability of oxidative phosphorylation subunits are reduced in a diet-induced mouse model of NAFLD. •These changes are associated with impaired activities of electron transport chain complexes and ATP synthesis. •Increased mitophagy contributed to enhanced degradation of mitochondrial proteins.

Keywords:	Protein Degradation Protein Turnover Mass Spectrometry Mitochondria function or biology Oxidative stress Energy metabolism heavy water metabolic labeling oxidative phosphorylation
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