A STUDY ON INEFFECTIVE ERYTHROPOIESIS IN THE DOG |
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| Authors: | Nicolas Odartchenko Hans Cottier Victor P Bond |
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| Institution: | Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland, Institute of Pathology, University of Bern, Bern, Switzerland, and Brookhaven National Laboratory, Upton, New York, U.S.A. |
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| Abstract: | Erythrocytic cell kinetics were studied in normal dog bone marrow, at the transition between younger cells that are able to synthesize DNA, and more mature nucleated normoblasts which have lost this ability. the rate of progression out of the first group was compared to that into the second, after necessary adjustments of group sizes. No significant discrepancy was detected within the limits of resolution of autoradiographic cytokinetic analysis.
It is concluded that 'ineffective' red cell production in the normal dog, if it occurs at all, can only be very small in quantity. |
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