The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells |
| |
Authors: | N Roehm L Herron J Cambier D DiGuisto K Haskins J Kappler P Marrack |
| |
Affiliation: | 1. Department of Molecular Genetics University of Texas Health Science Center at Dallas Southwestern Medical School Dallas, Texas 75235 USA;2. Department of Internal Medicine University of Texas Health Science Center at Dallas Southwestern Medical School Dallas, Texas 75235 USA |
| |
Abstract: | A monoclonal antibody, KJ16-133, which binds to antigen-specific, major histocompatibility complex-restricted (Ag/MHC) receptors on about 20% of BALB/c peripheral T cells has been used to examine the expression of these receptors on thymocytes and different subpopulations of peripheral T cells. Although KJ16-133-reactive receptors were found on mature thymocytes at similar frequencies and levels as on peripheral T cells, these molecules were absent from the first cells to enter the thymus, and in less mature thymocyte populations KJ16-133-reactive cells were less frequent than in the periphery and bore lower quantities of receptor. These results showed that Ag/MHC receptors are present on the surfaces of immature thymocytes, albeit at variable levels, during the time that the repertoire of these cells for Ag/MHC is thought to be selected. Additional experiments showed that KJ16-133 could not be used to distinguish T-cell receptors with different restriction specificities, i.e., for Class I or Class II products of the MHC. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|