Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines |
| |
| Authors: | Dang Zhao Yang Yushe Ji Ruyun Zhang Shuhua |
| |
| Affiliation: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| |
| Abstract: | The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
