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Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH) |
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| Authors: | Timmons Amy Seierstad Mark Apodaca Rich Epperson Matt Pippel Dan Brown Sean Chang Leon Scott Brian Webb Michael Chaplan Sandra R Breitenbucher J Guy |
| Affiliation: | Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. |
| Abstract: | Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats. |
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