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Design of potent inhibitors of human beta-secretase. Part 1 |
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| Authors: | Freskos John N Fobian Yvette M Benson Timothy E Bienkowski Michael J Brown David L Emmons Thomas L Heintz Robert Laborde Alice McDonald Joseph J Mischke Brent V Molyneaux John M Moon Joseph B Mullins Patrick B Bryan Prince D Paddock Donna J Tomasselli Alfredo G Winterrowd Gregory |
| Affiliation: | Pfizer Inc., 700N. Chesterfield Pkwy., St. Louis, MO 63198, USA. john.n.freskos@pfizer.com |
| Abstract: | We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided. |
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