Immunity to tetanus: tetanus antitoxin and anti-BIIb in human sera |
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| Authors: | M German-Fattal B Bizzini A German |
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| Institution: | 1. Astrid Lindgren children''s hospital, Karolinska University Hospital, Stockholm, Sweden;2. Department of Women''s and Children''s Health, Karolinska Institutet, Stockholm, Sweden;3. Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden;4. Department of Paediatrics, Futurum Academy of Health and Care, Jönköping, Sweden;5. Department of Biomedical and Clinical Sciences, Linköping University, Sweden;6. Department of Clinical Sciences, Lund University, Lund, Sweden |
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| Abstract: | Immunity to tetanus was investigated in 157 individuals aged between 1 and 77 years using, for the evaluation of both tetanus antitoxin and antibody to fragment BIIb (anti-BIIb), an easily performed ELISA that gave reproducible results. Among these people 72% were protected against tetanus (tetanus antitoxin titres greater than 0.06 IU ml-1). Anti-BIIb titres greater than 0.15 U ml-1 were found in 75% of the males vs 57% of the females (P less than 0.02) with marked variations according to age. Furthermore, 13 out of 41 individuals with antitoxin titres less than 0.06 IU ml-1 (not protected against tetanus) were found to have anti-BIIb titres greater than 0.15 U ml-1. These data raise questions as to the significance and protective effect of anti-BIIb against tetanus. |
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