NERVE: New Enhanced Reverse Vaccinology Environment |
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Authors: | Sandro Vivona Filippo Bernante and Francesco Filippini |
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Institution: | (1) Molecular Biology and Bioinformatics (MOLBINFO), Department of Biology, University of Padua, viale G. Colombo 3, 35131 Padova, Italy |
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Abstract: | Background Since a milestone work on Neisseria meningitidis B, Reverse Vaccinology has strongly enhanced the identification of vaccine candidates by replacing several experimental tasks
using in silico prediction steps. These steps have allowed scientists to face the selection of antigens from the predicted proteome of pathogens,
for which cell culture is difficult or impossible, saving time and money. However, this good example of bioinformatics-driven
immunology can be further developed by improving in silico steps and implementing biologist-friendly tools. |
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