Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression |
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| Authors: | Liping Huang Catherine P Kirschke Yunfan Zhang |
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| Institution: | (1) Western Human Nutrition Research Center/Agriculture Research Service/United States Department of Agriculture, Davis, California, USA;(2) Department of Nutrition, University of California at Davis, Davis, California, USA;(3) Rowe Program in Genetics, University of California at Davis, Davis, California, USA;(4) Department of Anatomy and Cell biology, Wayne State University, Detroit, Michigan, USA |
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| Abstract: | Background Zinc plays important roles in maintaining normal function of the prostate and in development of prostate malignancy. It has
been demonstrated that prostate malignant epithelial cells contain much less cellular zinc than the surrounding normal epithelial
cells. However, the pathway(s) which leads to lower zinc accumulation in malignant prostate epithelial cells is poorly understood.
In this study, the zinc homeostatic features of two human prostate epithelial cell lines (non-tumorigenic, RWPE1, and tumorigenic,
RWPE2) were investigated. Effects of over-expression of ZIP1 in RWPE2 on cell proliferation and apoptosis were also studied. |
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