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HybGFS: a hybrid method for genome-fingerprint scanning
Authors:Kosaku Shinoda   Nozomu Yachie   Takeshi Masuda   Naoyuki Sugiyama   Masahiro Sugimoto   Tomoyoshi Soga  Masaru Tomita
Affiliation:(1) Human Metabolome Technologies, Inc., Tsuruoka Yamagata, 997-0052, Japan;(2) Institute for Advanced Biosciences, Keio University, Tsuruoka Yamagata, 997-0017, Japan;(3) Department of Bioinformatics, Mitsubishi Space Software Co. Ltd., Amagasaki Hyogo, 661–001, Japan
Abstract:

Background  

Protein identification based on mass spectrometry (MS) has previously been performed using peptide mass fingerprinting (PMF) or tandem MS (MS/MS) database searching. However, these methods cannot identify proteins that are not already listed in existing databases. Moreover, the alternative approach of de novo sequencing requires costly equipment and the interpretation of complex MS/MS spectra. Thus, there is a need for novel high-throughput protein-identification methods that are independent of existing predefined protein databases.
Keywords:
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