Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos |
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Authors: | Eimear E Holohan Petra I zur Lage Andrew P Jarman |
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Institution: | (1) Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK;(2) Smurfit Institute of Genetics and TCIN, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland |
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Abstract: | Background The regulation of proneural gene expression is an important aspect of neurogenesis. In the study of the Drosophila proneural genes, scute and atonal, several themes have emerged that contribute to our understanding of the mechanism of neurogenesis. First, spatial complexity
in proneural expression results from regulation by arrays of enhancer elements. Secondly, regulation of proneural gene expression
occurs in distinct temporal phases, which tend to be under the control of separate enhancers. Thirdly, the later phase of
proneural expression often relies on positive autoregulation. The control of these phases and the transition between them
appear to be central to the mechanism of neurogenesis. We present the first investigation of the regulation of the proneural
gene, amos. |
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