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Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression |
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| Authors: | Jens Grote Simone König Doreen Ackermann Claudia Sopalla Malgorzata Benedyk Marek Los Claus Kerkhoff |
| Affiliation: | 1. Institute of Experimental Dermatology, University of Muenster, Muenster, Germany 2. Interdisciplinary Center for Clinical Research, Core Group Integrated Functional Genomics, Medical Faculty, University of Muenster, Muenster, Germany 4. Interdisciplinary Center for Clinical Research (IZKF) Münster, Muenster, Germany 3. Manitoba Institute of Cell Biology, Winnipeg, Canada |
| Abstract: | BackgroundS100 proteins, a multigenic family of non-ubiquitous cytoplasmic Ca2+-binding proteins, have been linked to human pathologies in recent years. Dysregulated expression of S100 proteins, including S100A9, has been reported in the epidermis as a response to stress and in association with neoplastic disorders. Recently, we characterized a regulatory element within the S100A9 promotor, referred to as MRE that drives the S100A9 gene expression in a cell type-specific, activation- and differentiation-dependent manner (Kerkhoff et al. (2002) J. Biol. Chem. 277, 41879–41887). |
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