Microbial identification by mass cataloging |
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| Authors: | Zhengdong Zhang George W Jackson George E Fox Richard C Willson |
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| Affiliation: | (1) Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204-5001, USA;(2) Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA;(3) Department of Chemical Engineering, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204-4004, USA;(4) BioTex, Inc., 8058 El Rio St., Houston, TX 77054, USA |
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| Abstract: | Background The public availability of over 180,000 bacterial 16S ribosomal RNA (rRNA) sequences has facilitated microbial identification and classification using hybridization and other molecular approaches. In their usual format, such assays are based on the presence of unique subsequences in the target RNA and require a prior knowledge of what organisms are likely to be in a sample. They are thus limited in generality when analyzing an unknown sample. |
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