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Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair |
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| Authors: | Judita Mascarenhas Humberto Sanchez Serkalem Tadesse Dawit Kidane Mahalakshmi Krisnamurthy Juan C Alonso Peter L Graumann |
| Affiliation: | 1. Institut für Mikrobiologie, Albert-Ludwigs Universit?t Freiburg, Stefan Meier Str. 19, 79104, Freiburg, Germany 3. Institut für Klinische Zytobiologie und Zytopathologie, Robert-Koch-Stra?e 6, 35037, Marburg, Germany 2. Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, C/Darwin 3, Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid, 28049, Spain |
| Abstract: | BackgroundSeveral distinct pathways for the repair of damaged DNA exist in all cells. DNA modifications are repaired by base excision or nucleotide excision repair, while DNA double strand breaks (DSBs) can be repaired through direct joining of broken ends (non homologous end joining, NHEJ) or through recombination with the non broken sister chromosome (homologous recombination, HR). Rad50 protein plays an important role in repair of DNA damage in eukaryotic cells, and forms a complex with the Mre11 nuclease. The prokaryotic ortholog of Rad50, SbcC, also forms a complex with a nuclease, SbcD, in Escherichia coli, and has been implicated in the removal of hairpin structures that can arise during DNA replication. Ku protein is a component of the NHEJ pathway in pro- and eukaryotic cells. |
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