Cytokine responses of bovine macrophages to diverse clinical Mycobacterium avium subspecies paratuberculosis strains |
| |
| Authors: | Harish K Janagama Kwang il Jeong Vivek Kapur Paul Coussens Srinand Sreevatsan |
| |
| Affiliation: | (1) Department of Veterinary Population Medicine, University of Minnesota, Saint Paul, MN, USA;(2) Food Animal Health Research Program, The Ohio State University, Wooster, OH, USA;(3) Biomedical Genomics Center and Department of Microbiology, University of Minnesota, St. Paul, MN, USA;(4) Department of Animal Science, Michigan State University, East Lansing, MI, USA |
| |
| Abstract: | Background Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease (JD) persistently infects and survives within the host macrophages. While it is established that substantial genotypic variation exists among MAP, evidence for the correlates that associate specific MAP genotypes with clinical or sub-clinical disease phenotypes is presently unknown. Thus we studied strain differences in intracellular MAP survival and host responses in a bovine monocyte derived macrophage (MDM) system. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
