Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: potential role of bacterial proteases in host signalling |
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| Authors: | Sonya Urnowey Toshihiro Ansai Vira Bitko Koji Nakayama Tadamichi Takehara and Sailen Barik |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, 307 University Blvd, 36688-0002 Mobile, Alabama, USA;(2) Department of Preventive Dentistry, Kyushu Dental College, 803-8580 Kitakyushu, Japan;(3) Division of Microbiology and Oral Infection, Nagasaki University Graduate School of Biomedical Sciences, 852-8588 Sakamoto 1-7-1, Nagasaki, Japan |
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| Abstract: | Background
Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant
destruction of the gingival tissue remain largely undefined. |
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