Multiple, non-allelic, intein-coding sequences in eukaryotic RNA polymerase genes |
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Authors: | Timothy JD Goodwin Margaret I Butler Russell TM Poulter |
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Affiliation: | (1) Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand |
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Abstract: | Background Inteins are self-splicing protein elements. They are translated as inserts within host proteins that excise themselves and ligate the flanking portions of the host protein (exteins) with a peptide bond. They are encoded as in-frame insertions within the genes for the host proteins. Inteins are found in all three domains of life and in viruses, but have a very sporadic distribution. Only a small number of intein coding sequences have been identified in eukaryotic nuclear genes, and all of these are from ascomycete or basidiomycete fungi. |
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