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Discovering functional gene expression patterns in the metabolic network of Escherichia coli with wavelets transforms
Authors:Rainer König  Gunnar Schramm  Marcus Oswald  Hanna Seitz  Sebastian Sager  Marc Zapatka  Gerhard Reinelt  Roland Eils
Institution:(1) Department of Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany;(2) Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;(3) Institute of Computer Science, University of Heidelberg, 69120 Heidelberg, Germany;(4) Interdisciplinary Center for Scientific Computing, University of Heidelberg, 69120 Heidelberg, Germany
Abstract:

Background  

Microarray technology produces gene expression data on a genomic scale for an endless variety of organisms and conditions. However, this vast amount of information needs to be extracted in a reasonable way and funneled into manageable and functionally meaningful patterns. Genes may be reasonably combined using knowledge about their interaction behaviour. On a proteomic level, biochemical research has elucidated an increasingly complete image of the metabolic architecture, especially for less complex organisms like the well studied bacterium Escherichia coli.
Keywords:
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