Discovering functional gene expression patterns in the metabolic network of Escherichia coli with wavelets transforms |
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Authors: | Rainer König Gunnar Schramm Marcus Oswald Hanna Seitz Sebastian Sager Marc Zapatka Gerhard Reinelt Roland Eils |
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Institution: | (1) Department of Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany;(2) Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;(3) Institute of Computer Science, University of Heidelberg, 69120 Heidelberg, Germany;(4) Interdisciplinary Center for Scientific Computing, University of Heidelberg, 69120 Heidelberg, Germany |
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Abstract: | Background Microarray technology produces gene expression data on a genomic scale for an endless variety of organisms and conditions.
However, this vast amount of information needs to be extracted in a reasonable way and funneled into manageable and functionally
meaningful patterns. Genes may be reasonably combined using knowledge about their interaction behaviour. On a proteomic level,
biochemical research has elucidated an increasingly complete image of the metabolic architecture, especially for less complex
organisms like the well studied bacterium Escherichia coli. |
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