Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling |
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| Authors: | John F LaDisa Jr Lars E Olson Hettrick A Douglas David C Warltier Judy R Kersten Paul S Pagel |
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| Institution: | (1) Department of Pediatrics (Division of Cardiology), Stanford University, Stanford, California, USA;(2) Department of Anesthesiology, the Medical College of Wisconsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA;(3) Department of Medicine (Division of Cardiovascular Diseases), the Medical College of Wisconsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA;(4) Department of Pharmacology and Toxicology, the Medical College of Wisconsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA;(5) Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA |
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| Abstract: | Background The success of stent implantation in the restoration of blood flow through areas of vascular narrowing is limited by restenosis.
Several recent studies have suggested that the local geometric environment created by a deployed stent may influence regional
blood flow characteristics and alter distributions of wall shear stress (WSS) after implantation, thereby rendering specific
areas of the vessel wall more susceptible to neointimal hyperplasia and restenosis. Stents are most frequently implanted in
curved vessels such as the coronary arteries, but most computational studies examining blood flow patterns through stented
vessels conducted to date use linear, cylindrical geometric models. It appears highly probable that restenosis occurring after
stent implantation in curved arteries also occurs as a consequence of changes in fluid dynamics that are established immediately
after stent implantation. |
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