Alpha interferon in T helper phenotype chronic lymphocytic leukemia: a report of three cases |
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Authors: | A Cuneo F Lanza R Spanedda P Tomasi L Ferrari G L Castoldi |
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Institution: | Chair of Hematology, University of Ferrara, Italy. |
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Abstract: | Three patients affected by T helper chronic lymphocytic leukemia were treated with low dose interferon alpha-2b (3 MU/m2 3 times weekly). The disease presented different pathologic expressions with diffuse skin lesions in one patient, a mild clinical course and a prolymphocytic variant with aggressive features, respectively, in the other two cases. A consistent response was observed within 3-6 weeks; by that time a reduction of blood and marrow lymphocytosis in the three patients and a regression of the cutaneous lesions were documented. Therefore, it should be emphasized that the use of alpha IFN, whose effectiveness on cutaneous T cell lymphomas has been already demonstrated, may represent an active agent in the treatment of leukemic T helper phenotype chronic lymphocytic proliferations. |
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