Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother |
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Authors: | Güven Ayla Aygun Canan Ince Hülya Aydin Murat Pinarli F Güçlü Baysal Kemal Küçüködük Sükrü |
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Institution: | Division of Endocrinology, Department of Pediatrics, Medical Faculty, Ondokuz Mayis University, TR-55200 Samsun, Turkey. aylaguven@yahoo.com |
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Abstract: | Hemangioendotheliomas can express type 3 iodothyronine deiodinase and cause severe hypothyroidism. The risk of congenital malformations such as vertebral and cardiac abnormalities in infants of diabetic mothers is higher than in babies of healthy women. Here we report an infant of a diabetic mother with hypothyroidism caused by liver hemangioendothelioma. Consumptive hypothyroidism should be an indicator to search for a vascular tumor in infants. Supranormal doses of L-thyroxine might be required for normalization of thyroid function until the tumor involutes or is resected. |
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